What medication classification is typically first prescribed for a client with hypertension unresponsive to lifestyle changes?

Thiazide diuretics are commonly prescribed as a first-line treatment for hypertension, particularly when lifestyle changes have not been sufficient to lower blood pressure. These medications work by promoting the excretion of sodium and water through the kidneys, which helps to reduce blood volume and, subsequently, blood pressure. Thiazide diuretics have a well-established track record in managing hypertension and are often favored because of their effectiveness, affordability, and low incidence of side effects.

In practice, the choice of thiazide diuretics is based on their proven ability to prevent cardiovascular complications, as they not only lower blood pressure but may also reduce the risk of heart disease and stroke in hypertensive patients. Given their role as first-line agents, thiazides are often the starting point in a treatment plan before considering other classifications of antihypertensive medications, particularly in cases where patients may also have risk factors such as heart failure or edema. This foundational approach highlights thiazide diuretics' central place in hypertension management.